Biomedical and metabolomics analysis

Innovation in Instrumentation and Analytical Strategies

Capillary electrophoresis and coupling to sensors for biomedical analysis and characterization of counterfeit drug
  • Simultaneous approach qual/quant as: development of the multiple injection
  • CE and MS (/ MS): evaluation of new coupling interfaces
  • CE and fluorescence: investigation of new bypass reactive
  • • CE and electrochemistry: coupling to the conductivity measurements and amperometric titration

Miniaturized sample preparation techniques for the extraction of polar compounds
  • liquid micro-extractions: EME, DLLME
  • solid micro-extractions online SPE μSPE
  • Handling of atypical biological fluids: cerebrospinal fluid, cell cultures, seminal fluid


In vitro, in vivo toxicity studies
  • Cellular models (2D and 3D)
  • Polar compounds analysis
Extended steroid profile
  • Serum, plasma, urine, seminal fluid analysis (>150 compounds)
  • Endocrine disruption (H295R)
  • Steroidogenesis evaluation
  • Environmental exposure (dioxin)
Metabolomics analysis
  • Targeted/untargeted acquisition in CE and LC-MS(/MS)
  • Normalization strategies
  • Retention time modeling
  • Database
Metabolism study
  • Cellular models (HLM)
  • Xenobiotics
  • Phase I and II biotransformations

Methodology and Data Analysis

Experimental design
  • Factor screening
  • Response surface for process optimization
Validation of analytical methods
  • Accuracy and uncertainty profiles
  • Quality by design
Development and application of chemometric tools for metabolomics
Multivariate analysis
  • Dimensionality reduction
  • Knowledge extraction
  • Machine learning
Clustering / Regression / Discriminant analysis / Classification
Advanced methods
  • Multiblock analysis
  • Multiway analysis
  • Megavariate analysis of variance