Welcome to the Molecular Pharmacology Group
at the School of Pharmaceutical Sciences
The overall aim of the Molecular Pharmacology Group’s research is the identification of optimized therapeutic strategies for the treatment of complex disease, mainly cancer. Our optimization strategy uses fundamental research to reveal the action mechanisms of the optimized drug mixtures. The latter, in turn, may identify novel signaling pathways, mechanisms of resistance and may lead to new drug discovery alleys.
The mainstays of the ongoing research are:
- design of personalized optimization of multidrug combinations,
- identification of novel targets for treatment,
- patient-derived 3D in vitro tumor models,
- cell fate mechanisms,
- overcoming acquired resistance of targeted drugs,
- alternative to mammalian screening models,
- nano-systems for co-delivery of multidrug combinations.
We work in a close collaboration with clinicians, engineers, biologists and medical oncologists in order to perform clinically relevant translational research to improve cancer treatment efficacy, reduce side effects and probability of a drug acquired resistance. Our ultimate goal is to develop personalized synergistic combination therapies to the dynamically changing tumor response.
- Prof. Patrycja Nowak-Sliwinska receives 2019 SGV award for the pioneer research for the 3Rs category
- Scientific picture taken by M. Zoetemelk (Nature Sci Rep 2019) selected as a Biomedical Picture of the Day by the London Institute of Medical Sciences: http://bpod.mrc.ac.uk/archive/2019/6/15
- Prof. Patrycja Nowak-Sliwinska in an interview for Radio Television Swiss: https://www.rts.ch/play/radio/cqfd/audio/la-3d-pour-tester-en-5-jours-les-traitements-personnalises?id=10420258&expandDescription=true. To see also at Avisdexperts.ch: http://www.avisdexperts.ch/videos/view/9884/1 and Interpharma.ch: https://newsroom.interpharma.ch/2019-06-03-zellplattform-unterstuetzt-personalisierte-krebstherapie
- Magdalena Rausch presents her project at the Cancer Seminar of the Translational Research Center in Oncohaematology: https://agenda.unige.ch/events/view/25619
- Our latest press release: https://www.unige.ch/communication/communiques/en/2019/la-3d-pour-tester-en-5-jours-les-traitements-personnalises/
- Magdalena Rausch selected to give a talk during the 7th Rare Diseases Summer School: https://www.radiz.uzh.ch/de/Rare-Diseases-Summer-School/SummerSchool2019.html